Angiogenesis: Cellular Transplantation of Bone Marrow Derived Stem Cells Following Myocardial Infarction

Study of:
To determine the safety, tolerability and efficacy of an intra-coronary infusion of autologous (one’s own) bone marrow derived stem cells compared to placebo (saline) in subjects with acute myocardial infarction (heart attack).

Recent studies have suggested that giving stem cells may minimize damage caused by a heart attack. This is a study in which some of a patient’s own bone marrow cells are infused into their heart’s vessels.

A total of 60 patients will be participating in this study. Patients will be randomized (like flipping a coin) to either receive a stem cell infusion into their heart’s vessels or to be infused with placebo (saline). There is a 2 out of 3 chance that patients will receive the stem cell infusion. Patients or their family will not be told which treatment they have been assigned. By not telling the patient (referred to as single-blinded), an unbiased assessment on how they think they are doing can be obtained which will help us answer the questions whether or not the bone marrow injections are effective. If a patient is randomized to the placebo group, they will be told at the 6 month follow-up visit and will receive the bone marrow injections shortly thereafter.

Jay H. Traverse, MD, FACC, FAHA

Rachel Olson, RN, MS, CCRC

For more information on this trial please contact Rachel Olson, RN at 612-863-3818.