Angiogenesis: Emerson Perin Autologous Bone Marrow MNCs via NOGA trial

Study of:

Recent studies have suggested that it may be possible to grow new blood vessels (angiogenesis) to supply to the heart muscle that is currently not getting enough blood. One theory, although still investigational and unproven, is that bone marrow cells may stimulate the growth of new blood vessels. This is a study in which some of a patient’s own bone marrow cells are injected into their heart muscle (using a specialized guiding and injection system) to try and improve the blood supply to your heart.

The purpose of this study is to determine the safety and effectiveness of these cells using this technique in people who are not optimal candidates for other forms of conventional therapy.

A total of 30 patients will be participating in this study. Patients will be randomized (like flipping a coin) to either receive bone marrow injections into their heart muscle or to be treated with standard medical therapy without the injections. There is a 2 out of 3 chance that patients will receive the bone marrow injections. Patients or their family will not be told which treatment they have been assigned. By not telling the patient (referred to as single-blinded), an unbiased assessment on how they think they are doing can be obtained which will help us answer the questions whether or not the bone marrow injections are effective. If a patient is randomized to the standard medical therapy without the injections, they will be told at the 6 month follow-up visit and may crossover to receive the bone marrow injections.

Timothy D. Henry, MD, FACC

Randall K. Johnson, MD, FACC

Anil K. Poulose, MD, FACC

Jay H. Traverse, MD, FACC, FAHA

Rachel Olson, RN, MS, CCRC

For more information on this trial please contact Rachel Olson, RN at 612-863-3818.