PBAV Study: Influence of External Beam Aortic Valve Radiation on Restenosis Following Successful Percutaneous Balloon Valvuloplasty in Elderly or Poor Surgical Risk Patients with Severe Aortic Stenosis

Study of:
External Beam Aortic Valve Radiation

Aortic stenosis is a narrowed aortic valve which occurs commonly in elderly patients. Treatment may include percutaneous balloon aortic valvuloplasty (PBAV), to open the aortic valve in a minimally invasive procedure using a catheter placed in the groin. This study will determine the safety of fractionated external beam radiation, for patients who have undergone successful PBAV, to limit renarrowing of the aortic valve.

This is a single-center, non-randomized study enrolling 15 patients > 80 years old who are not acceptable candidates or refuse aortic valve replacement surgery. Prior to the balloon valvuloplasty patients will undergo preliminary tests including an EBCT, Cardiac Echo and cardiac MRI. Follow-up will include 1-month, 6-month and yearly physician visits and cardiac echo for 5 years.

• Wesley R. Pedersen, MD, FACC

• Kevin M. Harris, MD, FACC, FASE
• Vib R. Kshettry, MD
• John R. Lesser, MD, FACC
• Terrence F. Longe, MD, FACC
• James D. Madison, MD, FACC
• Michael R. Mooney, MD, FACC
• Anil K. Poulose, MD, FACC
• Robert S. Schwartz, MD, FACC
• Robert A. Van Tassel, MD, FACC

• Talia Pierce, RN

For more information about this study or the Interventional Cardiology Research program at the Minneapolis Heart Institute and Minneapolis Heart Institute Foundation, please contact Carol Stone at 612-863-9124.